\[ \boxed { {\frac {\rm d}{{\rm d}x}}y \left ( x \right ) -\sqrt { \left ( {\it b4}\, \left ( y \left ( x \right ) \right ) ^{4}+{\it b3}\, \left ( y \left ( x \right ) \right ) ^{3}+{\it b2}\, \left ( y \left ( x \right ) \right ) ^{2}+{\it b1}\,y \left ( x \right ) +{\it b0} \right ) \left ( {\it a4}\,{x}^{4}+{\it a3}\,{x}^{3}+{\it a2}\,{x}^{2}+{\it a1}\,x+{\it a0} \right ) }=0} \]
Mathematica: cpu = 53.802332 (sec), leaf count = 12750 \[ \text {Failed to compile Latex} \]
Maple: cpu = 0.109 (sec), leaf count = 111 \[ \left \{ \int ^{y \left ( x \right ) }\!{\frac {1}{\sqrt {{{\it \_a}}^{4 }{\it b4}+{{\it \_a}}^{3}{\it b3}+{{\it \_a}}^{2}{\it b2}+{\it \_a}\,{ \it b1}+{\it b0}}}}{d{\it \_a}}+\int ^{x}\!-{1\sqrt { \left ( {\it b4} \, \left ( y \left ( x \right ) \right ) ^{4}+{\it b3}\, \left ( y \left ( x \right ) \right ) ^{3}+{\it b2}\, \left ( y \left ( x \right ) \right ) ^{2}+{\it b1}\,y \left ( x \right ) +{\it b0} \right ) \left ( {{\it \_a} }^{4}{\it a4}+{{\it \_a}}^{3}{\it a3}+{{\it \_a}}^{2}{\it a2}+{\it \_a }\,{\it a1}+{\it a0} \right ) }{\frac {1}{\sqrt {{\it b4}\, \left ( y \left ( x \right ) \right ) ^{4}+{\it b3}\, \left ( y \left ( x \right ) \right ) ^{3}+{\it b2}\, \left ( y \left ( x \right ) \right ) ^{2}+{\it b1}\,y \left ( x \right ) +{\it b0}}}}}{d{\it \_a}}+{\it \_C1}=0 \right \} \]
Sage: cpu = 0 (sec), leaf count = 0 \[ \text {Maxima was unable to solve this ODE} \]