\[ a e^{-2 x} y(x)+y''(x)+y'(x)=0 \] ✓ Mathematica : cpu = 0.0181857 (sec), leaf count = 37
\[\left \{\left \{y(x)\to c_1 \cos \left (\sqrt {a} e^{-x}\right )-c_2 \sin \left (\sqrt {a} e^{-x}\right )\right \}\right \}\]
✓ Maple : cpu = 0.121 (sec), leaf count = 27
\[ \left \{ y \left ( x \right ) ={\it \_C1}\,\sin \left ( {{\rm e}^{-x}}\sqrt {a} \right ) +{\it \_C2}\,\cos \left ( {{\rm e}^{-x}}\sqrt {a} \right ) \right \} \]
\[ y^{\prime \prime }+y^{\prime }+ae^{-2x}y=0 \]
Let \(y\left ( x\right ) =\eta \left ( \xi \right ) \) where \(\xi =e^{-x}\), hence
\begin {align*} \frac {dy}{dx} & =\frac {d\eta }{d\xi }\frac {d\xi }{dx}\\ & =\frac {d\eta }{d\xi }\left ( -e^{-x}\right ) \end {align*}
And
\begin {align*} \frac {d^{2}y}{dx^{2}} & =\frac {d}{dx}\left ( \frac {d\eta }{d\xi }\left ( -e^{-x}\right ) \right ) \\ & =\frac {d^{2}\eta }{d\xi ^{2}}\frac {d\xi }{dx}\left ( -e^{-x}\right ) +\frac {d\eta }{d\xi }\left ( e^{-x}\right ) \\ & =\frac {d^{2}\eta }{d\xi ^{2}}\left ( -e^{-x}\right ) \left ( -e^{-x}\right ) +\frac {d\eta }{d\xi }\left ( e^{-x}\right ) \\ & =\frac {d^{2}\eta }{d\xi ^{2}}\left ( e^{-2x}\right ) +\frac {d\eta }{d\xi }\left ( e^{-x}\right ) \end {align*}
Hence the original ODE becomes
\begin {align*} \frac {d^{2}\eta }{d\xi ^{2}}\left ( e^{-2x}\right ) +\frac {d\eta }{d\xi }\left ( e^{-x}\right ) +\frac {d\eta }{d\xi }\left ( -e^{-x}\right ) +ae^{-2x}\eta \left ( \xi \right ) & =0\\ \eta ^{\prime \prime }+a\eta & =0 \end {align*}
This is standard second order with constant coefficients. The solution is
\[ \eta =c_{1}\cos \left ( \sqrt {a}\xi \right ) +c_{2}\sin \left ( \sqrt {a}\xi \right ) \]
Substituting back
\[ y\left ( x\right ) =c_{1}\cos \left ( \sqrt {a}e^{-x}\right ) +c_{2}\sin \left ( \sqrt {a}e^{-x}\right ) \]
Verification
restart; ode:=diff(diff(y(x),x),x)+diff(y(x),x)+a*exp(-2*x)*y(x)=0; ys:=_C1*cos(sqrt(a)*exp(-x))+_C2*sin(sqrt(a)*exp(-x)); odetest(y(x)=ys,ode); 0